1. TARGETING KEY INFLAMMATION PATHWAYS

LithoLexal® JOINT-FLEX PRO targets key inflammation pathways to address The Vicious Cycle of Damage & Inflammation in Osteoarthritis.

It effectively suppresses the NF-κB pathway, a critical regulator of immune responses and inflammation. By inhibiting NF-κB activation, LithoLexal® JOINT-FLEX PRO decreases the production of pro-inflammatory cytokines like TNF-α and IL-1β, which play significant roles in osteoarthritis progression.

Additionally, it limits the synthesis of cyclooxygenase-2 (COX-2) and related prostaglandins, further reducing inflammation. This comprehensive approach not only prevents cartilage damage but also helps alleviate the symptoms associated with osteoarthritis.

2. CARTILAGE PROTEOGLYCAN REPLACEMENT THERAPY

Proteoglycans are large, complex molecules found in cartilage. They are composed of proteins and sugars and help provide structural support essential for cushioning joints and facilitating smooth movement.

Cartilage Proteoglycan Replacement Therapy with LithoLexal® JOINT-FLEX PRO works by:

  • REPLENISHING PROTEOGLYCANS
    Since proteoglycan depletion during the initial stages of cartilage damage is reversible (while advanced destruction of collagen fibres is not), replacing proteoglycans may prevent advanced and irreversible joint degradation.
  • RESTORING CARTILAGE FUNCTION
    With increased proteoglycan density, the therapy aims to enhance the cartilage’s ability to absorb impact and facilitate joint movement, effectively restoring and maintaining joint function and comfort.

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3. ENHANCING CARTILAGE REPAIR AND REMODELLING

LithoLexal® JOINT-FLEX PRO promotes cartilage repair by restoring homeostatic balance to cartilage remodelling processes.

  • Through Proteoglycan Replacement Therapy, it enhances the production of proteoglycans and collagen, essential components for cartilage structure and function.
  • By inhibiting key inflammatory pathways, particularly the NF-κB signalling, LithoLexal® JOINT-FLEX PRO reduces the catabolic activities that degrade cartilage.
  • It supports the rebalancing of cellular processes in cartilage synthesis and breakdown, fostering an environment conducive to cartilage repair and regeneration.

This multi-dimensional approach helps to restore cartilage integrity and function, effectively contributing to improved joint health and mobility in osteoarthritis patients.

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